Ontourage -
Bi-level giant club packs them in from the suburbs on weekends for good reason - the scene is young, attractive and full of energy. Be prepared to wait on line, but once you're in the space, which opened in Summer 2004 in the former home of Dennis Rodman's "Illusions" club, you won't want to leave. Weeknights are significantly less packed but provide the same energy and great music.
The retro-futuristic decor provides plenty of mirrored surfaces for primping and preening, and the VIP lounge is exactly that - be prepared to show some serious green to get in, even though the club itself boasts a mere $10 cover.